The genome and glioblastoma

The Cancer Genome Atlas Project is an NIH-sponsored program to systematically catalog the genetic alterations in human cancers. The first cancer type investigated is Glioblastoma multiforme (GBM), the most common and most aggressive form of brain cancer.

The Cancer Genome Atlas (TCGA) group has recently discovered that there are actually 4 genenic types of glioblastoma multiforme and that this information might help in figuring out why some clinical trials work for some patients but not all patients

Now that the genome for this cancer has been mapped, scientist can use this information to help develop targeted gene therapies.  For example : \

Further statistical analysis of the TCGA data revealed that miR-26a likely inhibits, or targets, three tumor suppressor genes called PTEN, RB1 and MAP3K2/MEKK2.  These genes are frequently mutated in many other cancers.  The researchers guessed that miR-26a aids GBM development by turning off these tumor suppressors.


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